The Receptor Tyrosine Phosphatase Crypα Promotes Intraretinal Axon Growth

@article{Ledig1999TheRT,
  title={The Receptor Tyrosine Phosphatase Crypα Promotes Intraretinal Axon Growth},
  author={Matthias M. Ledig and Fawaz Haj and John L. Bixby and Andrew William Stoker and Bernhard K. Mueller},
  journal={The Journal of Cell Biology},
  year={1999},
  volume={147},
  pages={375 - 388}
}
Retinal ganglion cell axons grow towards the optic fissure in close contact with the basal membrane, an excellent growth substratum. One of the ligands of receptor tyrosine phosphatase CRYPalpha is located on the retinal and tectal basal membranes. To analyze the role of this RPTP and its ligand in intraretinal growth and guidance of ganglion cell axons, we disrupted ligand- receptor interactions on the retinal basal membrane in culture. Antibodies against CRYPalpha strongly reduced retinal… CONTINUE READING

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