The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo

  title={The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo},
  author={T. Dechiara and D. Bowen and D. Valenzuela and M. Simmons and W. Poueymirou and S. Thomas and Erika Kinetz and D. Compton and E. Rojas and J. Park and C. Smith and P. Distefano and D. Glass and S. Burden and G. Yancopoulos},
  • T. Dechiara, D. Bowen, +12 authors G. Yancopoulos
  • Published 1996
  • Biology, Medicine
  • Cell
  • Formation of neuromuscular synapses requires a series of inductive interactions between growing motor axons and differentiating muscle cells, culminating in the precise juxtaposition of a highly specialized nerve terminal with a complex molecular structure on the postsynaptic muscle surface. The receptors and signaling pathways mediating these inductive interactions are not known. We have generated mice with a targeted disruption of the gene encoding MuSK, a receptor tyrosine kinase selectively… CONTINUE READING
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