The Receptor Recycling Pathway Contains Two Distinct Populations of Early Endosomes with Different Sorting Functions

@article{Sheff1999TheRR,
  title={The Receptor Recycling Pathway Contains Two Distinct Populations of  Early Endosomes with Different Sorting Functions },
  author={David R. Sheff and Elizabeth A. Daro and Michael Hull and Ira Mellman},
  journal={The Journal of Cell Biology},
  year={1999},
  volume={145},
  pages={123 - 139}
}
Receptor recycling involves two endosome populations, peripheral early endosomes and perinuclear recycling endosomes. In polarized epithelial cells, either or both populations must be able to sort apical from basolateral proteins, returning each to its appropriate plasma membrane domain. However, neither the roles of early versus recycling endosomes in polarity nor their relationship to each other has been quantitatively evaluated. Using a combined morphological, biochemical, and kinetic… CONTINUE READING
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