The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast.

@article{Groocock2012TheRO,
  title={The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast.},
  author={Lynda M. Groocock and John F. Prudden and John Jefferson Piers Perry and Michael N Boddy},
  journal={Molecular and cellular biology},
  year={2012},
  volume={32 2},
  pages={
          276-87
        }
}
Of the five human RecQ family helicases, RecQ4, BLM, and WRN suppress distinct genome instability-linked diseases with severe phenotypes, often with indeterminate etiologies. Here, we functionally define Hrq1, a novel orthologue of RecQ4 from fission yeast. Biochemical analysis of Hrq1 reveals a DEAH box- and ATP-dependent 3'-5' helicase activity on various DNA substrates, including bubbles but not blunt duplexes, characteristic of the RecQ family. Cells lacking Hrq1 suffer spontaneous genomic… CONTINUE READING
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Saccharomyces cerevisiae Hrq1 requires a long 3'-tailed DNA substrate for helicase activity.

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