The Reaction between Actomiyosin and Adenosine Triphosphate*

  • Published 2003


The modern tendency in the biochemistry of muscle is to consider the enzymatic dephosphorylation of adenosine triphosphate (ATP) as the energyyielding reaction of muscular activity. In a preceding paper by Mommaerts and Seraidarian (16) it was demonstrated that there are serious objections to this viewpoint, which currently seems to be untenable. The main experimental basis for this conclusion was the demonstration that the hydrolysis of ATP by myosin-ATPase can account at most for only a small percentage of the speed of breakdown of ATP in contracting muscle as actually observed. Even before this development, the criticism could have been made that the proponents of what may be called the myosin-enzyme theory failed to make the mechanism of the energy transfer clear. It is stated repeatedly (e.g. Dainty et al., 9) that the reaction energy of the hydrolysis of ATP, supposedly of the order of magnitude of 10,000 calories per mol phosphate, is somehow given over to the myosin, but no explanation of the mechanism of this transfer has been attempted. Extremely valuable contributions have been made by A. Szent-GySrgyi (23), independently of any theory. He showed that myosin reacts with ATP, and that various physical changes can be evoked in actomyosin as a result of this reaction. In an earlier publication (12) the author showed that this reaction is actually a combination between ATP and myosin, but the methods were imperfect and the mechanism was not worked out in detail. It is the purpose of this paper to present a preliminary analysis of the combination between ATP and myosin, and of some of the physical phenomena resulting from it. The most striking of the effects discovered by Szent-Gy6rgyi is certainly the contraction of actomyosin threads under influence of ATP (22, 23). For several reasons, however, this phenomenon is not well suited to

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@inproceedings{TRIPHOSPHATE2003TheRB, title={The Reaction between Actomiyosin and Adenosine Triphosphate*}, author={ADENOSINE TRIPHOSPHATE}, year={2003} }