The Rb binding domain of HPV31 E7 is required to maintain high levels of DNA repair factors in infected cells.

@article{Johnson2017TheRB,
  title={The Rb binding domain of HPV31 E7 is required to maintain high levels of DNA repair factors in infected cells.},
  author={Bryan A Johnson and Heather L. Aloor and Cary A. Moody},
  journal={Virology},
  year={2017},
  volume={500},
  pages={22-34}
}
Human papillomaviruses (HPV) exhibit constitutive activation of ATM and ATR DNA damage response (DDR) pathways, which are required for productive viral replication. Expression of HPV31 E7 alone is sufficient to activate the DDR through an unknown mechanism. Here, we demonstrate that the E7 Rb binding domain is required to increase levels of many DDR proteins, including ATM, Chk2, Chk1, the MRN components MRE11, Rad50, and NBS1, as well as the homologous recombination repair proteins BRCA1 and… CONTINUE READING
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