The Ratio of Osteocytic Incorporation to Bone Matrix Formation in Femoral Neck Cancellous Bone: An Enhanced Osteoblast Work Rate in the Vicinity of Hip Osteoarthritis

Abstract

Recently it has been shown that an inactivating mutation in the TGFb-SMAD3 signaling pathway, which increases the conversion of osteoblasts to osteocytes, is accompanied by bone loss combined with increased osteocyte density. We hypothesized that increased matrix TGFb, known to occur in osteoarthritis, might cause the reverse of these effects in man… (More)
DOI: 10.1007/s00223-001-2134-3

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@article{Jordan2003TheRO, title={The Ratio of Osteocytic Incorporation to Bone Matrix Formation in Femoral Neck Cancellous Bone: An Enhanced Osteoblast Work Rate in the Vicinity of Hip Osteoarthritis}, author={Gary Jordan and N. Loveridge and J. Power and Michael T Clarke and M. Parker and Joanne Reeve}, journal={Calcified Tissue International}, year={2003}, volume={72}, pages={190-196} }