The Ratio of 2-AG to Its Isomer 1-AG as an Intrinsic Fine Tuning Mechanism of CB1 Receptor Activation

@inproceedings{Dcs2017TheRO,
  title={The Ratio of 2-AG to Its Isomer 1-AG as an Intrinsic Fine Tuning Mechanism of CB1 Receptor Activation},
  author={Klaudia D{\'o}cs and Zolt{\'a}n M{\'e}sz{\'a}r and S{\'a}ndor Gonda and Attila Kiss-Szikszai and Krisztina Holl{\'o} and Miklos Antal and Zolt{\'a}n Hegyi},
  booktitle={Front. Cell. Neurosci.},
  year={2017}
}
Endocannabinoids are pleiotropic lipid messengers that play pro-homeostatic role in cellular physiology by strongly influencing intracellular Ca2+ concentration through the activation of cannabinoid receptors. One of the best-known endocannabinoid '2-AG' is chemically unstable in aqueous solutions, thus its molecular rearrangement, resulting in the formation of 1-AG, may influence 2-AG-mediated signaling depending on the relative concentration and potency of the two isomers. To predict whether… CONTINUE READING

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