The Ras superfamily of GTPases.

  title={The Ras superfamily of GTPases.},
  author={Ian G. Macara and Karen M. Lounsbury and Stephanie Richards and COLLEEN J. MCKIERNAN and Dafna Bar-Sagi},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={10 5},
The Ras superfamily of small GTPases comprises a group of molecular switches that regulate an astonishing diversity of cellular functions. A deep understanding of mitogenesis, cytoskeletal organization, vesicle traffic, and nuclear transport now requires the inclusion of the small GTPases as essential components of the molecular machines that drive these processes. The rich complexity of the control mechanisms involved is evidenced by the recent discoveries of GTPase cascades, multiple… CONTINUE READING

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