The Ras signaling pathway mediates cetuximab resistance in nasopharyngeal carcinoma.

Abstract

This work aimed to investigate the role of the Ras signaling pathway in cetuximab resistance in human nasopharyngeal carcinoma (hNPC). An hNPC 5-8F cell line was induced by stepwise exposure to increasing doses of cetuximab. Western blot was conducted to detect protein levels. Our results are as follows: cetuximab-resistant hNPC 5-8F/Erbitux cell lines were… (More)
DOI: 10.1016/j.biopha.2011.02.005

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