The Ras-related GTPase Rac1 binds tubulin.

  title={The Ras-related GTPase Rac1 binds tubulin.},
  author={Aaron Best and Sohail Ahmed and R. Kozma and Louis Lim},
  journal={The Journal of biological chemistry},
  volume={271 7},
The Ras-related Rho family are involved in controlling actin-based changes in cell morphology. Microinjection of Rac1, RhoA, and Cdc42Hs into Swiss 3T3 cells induces pinocytosis and membrane ruffling, stress fiber formation, and filopodia formation, respectively. To identify target proteins involved in these signaling pathways cell extracts immobilized on nitrocellulose have been probed with [gamma-32P]GTP-labeled Rac1, RhoA, and Cdc42Hs. We have identified two 55-kDa brain proteins which bind… CONTINUE READING

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