The Ras protein superfamily: Evolutionary tree and role of conserved amino acids

@inproceedings{Rojas2012TheRP,
  title={The Ras protein superfamily: Evolutionary tree and role of conserved amino acids},
  author={Ana Mar{\'i}a Rojas and Gerardo Rodr{\'i}guez Fuentes and Antonio Rausell and A. Fern{\'a}ndez Valencia},
  booktitle={The Journal of cell biology},
  year={2012}
}
The Ras superfamily is a fascinating example of functional diversification in the context of a preserved structural framework and a prototypic GTP binding site. Thanks to the availability of complete genome sequences of species representing important evolutionary branch points, we have analyzed the composition and organization of this superfamily at a greater level than was previously possible. Phylogenetic analysis of gene families at the organism and sequence level revealed complex… CONTINUE READING
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