The Ras-Raf pathway is activated in human immunodeficiency virus-infected monocytes and particpates in the activation of NF-kappa B.

@article{Folgueira1996TheRP,
  title={The Ras-Raf pathway is activated in human immunodeficiency virus-infected monocytes and particpates in the activation of NF-kappa B.},
  author={Lola Folgueira and Alicia Algeciras and W S MacMorran and Gary D. Bren and Carlos V. Paya},
  journal={Journal of virology},
  year={1996},
  volume={70 4},
  pages={2332-8}
}
Persistent human immunodeficiency virus (HIV) infection of human monocytes and macrophages increases I kappa B alpha degradation, resulting in the activation of NF-kappa B, a key transcription factor in the regulation of the HIV long terminal repeat. The signal transduction pathways leading to NF-kappa B activation in cells of the monocytic lineage, especially those regulated by HIV infection, and their relevance in regulating viral persistence remain unknown. Both p21ras and its downstream Raf… CONTINUE READING

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