The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation.

  title={The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation.},
  author={Michelle C. Mendoza and Ekrem Emrah Er and John Blenis},
  journal={Trends in biochemical sciences},
  volume={36 6},
The Ras-extracellular signal-regulated kinase (Ras-ERK) and phosphatidylinositol 3-kinase-mammalian target of rapamycin (PI3K-mTOR) signaling pathways are the chief mechanisms for controlling cell survival, differentiation, proliferation, metabolism, and motility in response to extracellular cues. Components of these pathways were among the first to be discovered when scientists began cloning proto-oncogenes and purifying cellular kinase activities in the 1980s. Ras-ERK and PI3K-mTOR were… CONTINUE READING