The Ras/MAPK cascade and the control of positive selection.

@article{AlberolaIla2003TheRC,
  title={The Ras/MAPK cascade and the control of positive selection.},
  author={Jos{\'e} Alberola-Ila and Gabriela Hern{\'a}ndez-Hoyos},
  journal={Immunological reviews},
  year={2003},
  volume={191},
  pages={79-96}
}
Immature double positive (DP) thymocytes bearing a T cell receptor (TCR) that interacts with self-major histocompatibility complex (MHC) molecules receive signals that induce either their differentiation (positive selection) or apoptosis (negative selection). Furthermore, those cells that are positively selected develop into two different lineages, CD4 or… CONTINUE READING