The Rapidly Evolving Role of Titin in Cardiac Physiology and Cardiomyopathy.

@article{Gerull2015TheRE,
  title={The Rapidly Evolving Role of Titin in Cardiac Physiology and Cardiomyopathy.},
  author={Brenda Gerull},
  journal={The Canadian journal of cardiology},
  year={2015},
  volume={31 11},
  pages={1351-9}
}
The giant muscle filament protein titin is encoded by a single gene consisting of 364 exons. In the past, because of its enormous size and complexity, only few titin mutations were discovered causing different cardiac and skeletal muscle conditions; however, the overall role for heritable diseases, in particular dilated cardiomyopathy (DCM), has been significantly underestimated. Recently performed systematic studies using next-generation sequencing (NGS) recognized TTN as the major human… CONTINUE READING

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