The Rapamune era of immunosuppression 2003: the journey from the laboratory to clinical transplantation.

@article{Camardo2003TheRE,
  title={The Rapamune era of immunosuppression 2003: the journey from the laboratory to clinical transplantation.},
  author={Joseph S. Camardo},
  journal={Transplantation proceedings},
  year={2003},
  volume={35 3 Suppl},
  pages={18S-24S}
}
The story of Rapamune (sirolimus, rapamycin) began with the isolation of an antibiotic from a soil sample sent to Ayerst Laboratories in Montreal. More than 25 years later, sirolimus was approved for use by transplant physicians in the United States. Development programs for new drugs for transplantation face significant challenges. Four key challenges were critical to the development of sirolimus as a drug for transplantation: First, sirolimus was not intended to be an antirejection agent… CONTINUE READING

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