The Rak/Frk tyrosine kinase associates with and internalizes the epidermal growth factor receptor

@article{Jin2014TheRT,
  title={The Rak/Frk tyrosine kinase associates with and internalizes the epidermal growth factor receptor},
  author={Liting Jin and Rolf Joseph Craven},
  journal={Oncogene},
  year={2014},
  volume={33},
  pages={326-335}
}
Src is the founding member of a diverse family of intracellular tyrosine kinases, and Src has a key role in promoting cancer growth, in part, through its association with receptor tyrosine kinases. However, some Src-related proteins have widely divergent physiological roles, and these proteins include the Rak/Frk tyrosine kinase (Frk stands for Fyn-related kinase), which inhibits cancer cell growth and suppresses tumorigenesis. Rak/Frk phosphorylates and stabilizes the Pten tumor suppressor… CONTINUE READING