The Rad53 signal transduction pathway: Replication fork stabilization, DNA repair, and adaptation.

@article{Branzei2006TheRS,
  title={The Rad53 signal transduction pathway: Replication fork stabilization, DNA repair, and adaptation.},
  author={Dana Branzei and Marco Foiani},
  journal={Experimental cell research},
  year={2006},
  volume={312 14},
  pages={2654-9}
}
Cells are continually exposed to genomic insults resulting from exogenous and endogenous damage as well as by challenges posed by DNA replication. In order to maintain genome integrity, the cells must monitor and coordinate different aspects of chromosome metabolism with cell cycle events that are performed in a predetermined order. Checkpoints are cellular surveillance and signaling pathways that coordinate these physiological responses, and growing evidence suggests that failure of these… CONTINUE READING

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