The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes.

@article{Croker2002TheRG,
  title={The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes.},
  author={Ben A Croker and David M Tarlinton and Leonie A. Cluse and Alana Jane Tuxen and Amanda Light and Fengchun Yang and David A Williams and Andrew W Roberts},
  journal={Journal of immunology},
  year={2002},
  volume={168 7},
  pages={3376-86}
}
We have defined roles for the hemopoietic-specific Rho guanosine triphosphatase, Rac2, in B lymphocyte development and function through examination of rac2(-/-) mice. Rac2-deficient mice displayed peripheral blood B lymphocytosis and marked reductions in peritoneal cavity B-1a lymphocytes, marginal zone B lymphocytes, and IgM-secreting plasma cells as well… CONTINUE READING