The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin

Abstract

Rho GTPases control actin reorganization and many other cellular functions. Guanine nucleotide-exchange factors (GEFs) activate Rho GTPases by promoting their exchange of GDP for GTP. Trio is a unique Rho GEF, because it has separate GEF domains, GEFD1 and GEFD2, that control the GTPases RhoG/Rac1 and RhoA, respectively. Dbl-homology (DH) domains that are… (More)
DOI: 10.1038/35046533

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