The Rac1/JNK pathway is critical for EGFR-dependent barrier formation in human airway epithelial cells.

@article{Terakado2011TheRP,
  title={The Rac1/JNK pathway is critical for EGFR-dependent barrier formation in human airway epithelial cells.},
  author={Masahiro Terakado and Y Gon and Akiko Sekiyama and Ikuko Takeshita and Yutaka Kozu and Ken Matsumoto and Noriaki Takahashi and Shu Hashimoto},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2011},
  volume={300 1},
  pages={L56-63}
}
The airway epithelial barrier provides defenses against inhaled antigens and pathogens, and alterations of epithelial barrier function have been proposed to play a significant role in the pathogenesis of chronic airway diseases. Although the epidermal growth factor receptor (EGFR) plays roles in various physiological and pathological processes on the airway epithelium, the role of EGFR on barrier function in the airway remains largely unknown. In the present study, we assessed the effects of… CONTINUE READING