The Rac GEF ZizB regulates development, cell motility and cytokinesis in Dictyostelium.

@article{Pakes2012TheRG,
  title={The Rac GEF ZizB regulates development, cell motility and cytokinesis in Dictyostelium.},
  author={Nicholl K. Pakes and Douwe M Veltman and Francisco Rivero and Jamal Nasir and Robert Insall and Robin S B Williams},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 10},
  pages={2457-65}
}
Dock (dedicator of cytokinesis) proteins represent a family of guanine nucleotide exchange factors (GEFs) that include the well-studied Dock180 family and the poorly characterised zizimin family. Our current understanding of Dock180 function is that it regulates Rho small GTPases and thus has a role in a number of cell processes, including cell migration, development and division. Here, we use a tractable model for cell motility research, Dictyostelium discoideum, to help elucidate the role of… CONTINUE READING
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