The Rac 1 C-terminal Polybasic Region Regulates the Nuclear Localization and Protein Degradation of Rac 1 *

@inproceedings{Lanning2004TheR1,
  title={The Rac 1 C-terminal Polybasic Region Regulates the Nuclear Localization and Protein Degradation of Rac 1 *},
  author={Cathy Cole Lanning and Janelle L. Daddona and Rebecca Ruiz-Velasco and Shulamith H. Shafer and Carol L. Williams},
  year={2004}
}
We observed evolutionary conservation of canonical nuclear localization signal sequences (K(K/R)X(K/R)) in the C-terminal polybasic regions (PBRs) of some Rac and Rho isoforms. Canonical D-box sequences (RXXL), which target proteins for proteasome-mediated degradation, are also evolutionarily conserved near the PBRs of these small GTPases. We show that the Rac1 PBR (PVKKRKRK) promotes Rac1 nuclear accumulation, whereas the RhoA PBR (RRGKKKSG) keeps RhoA in the cytoplasm. A mutant Rac1 protein… CONTINUE READING

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C-terminal Polybasic Regions of Rac1 and RhoA

M. Pop, K. Aktories, G. Schmidt
J. Biol. Chem. 279, • 2004

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