The Rab5 effector EEA1 interacts directly with syntaxin-6.

  title={The Rab5 effector EEA1 interacts directly with syntaxin-6.},
  author={Anne Simonsen and J M Gaullier and A D'Arrigo and Harald Stenmark},
  journal={The Journal of biological chemistry},
  volume={274 41},
The fusion of transport vesicles with their cognate target membranes, an essential event in intracellular membrane trafficking, is regulated by SNARE proteins and Rab GTPases. Rab GTPases are thought to act prior to SNAREs in vesicle docking, but the exact biochemical relationship between the two classes of molecules is not known. We recently identified the early endosomal autoantigen EEA1 as an effector of Rab5 in endocytic membrane fusion. Here we demonstrate that EEA1 interacts directly and… CONTINUE READING


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