The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane

Abstract

Granuphilin, an effector of the small GTPase Rab27a, mediates the stable attachment (docking) of insulin granules to the plasma membrane and inhibits subsequent fusion of docked granules, possibly through interaction with a fusion-inhibitory Munc18-1/syntaxin complex. However, phenotypes of insulin exocytosis differ considerably between Rab27a- and… (More)
DOI: 10.1091/mbc.E12-04-0265

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