The Rab family of proteins: 25 years on.

@article{Kelly2012TheRF,
  title={The Rab family of proteins: 25 years on.},
  author={Eoin E. Kelly and Conor P. Horgan and Bruno Goud and Mary W Mccaffrey},
  journal={Biochemical Society transactions},
  year={2012},
  volume={40 6},
  pages={
          1337-47
        }
}
Intracellular membrane trafficking requires the complex interplay of several classes of trafficking proteins. Rab proteins, the largest subfamily of the Ras superfamily of small G-proteins, are central regulators of all aspects of intracellular trafficking processes including vesicle budding and uncoating, motility, tethering and fusion. In the present paper, we discuss the discovery, evolution and characterization of the Rab GTPase family. We examine their basic functional roles, their… 
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