The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis.

@article{Cheviet2004TheRP,
  title={The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis.},
  author={S{\'e}verine Cheviet and Thierry Coppola and Lee P. Haynes and Robert D. Burgoyne and Romano Regazzi},
  journal={Molecular endocrinology},
  year={2004},
  volume={18 1},
  pages={117-26}
}
The small GTPases Rab3 and Rab27 are associated with secretory granules of pancreatic beta-cells and regulate insulin exocytosis. In this study, we investigated the role of Noc2, a potential partner of these two GTPases, in insulin secretion. In the beta-cell line INS-1E wild-type Noc2, Noc265E, and Noc258A, a mutant capable of interacting with Rab27 but not Rab3, colocalized with insulin-containing vesicles. In contrast, two mutants (Noc2138S,141S and Noc2154A,155A,156A) that bind neither Rab3… CONTINUE READING

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