The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

  title={The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size},
  author={Lara Planas-Paz and Vanessa Orsini and Luke Boulter and Diego Calabrese and Monika Pikiolek and Florian Nigsch and Yang Xie and Guglielmo Roma and Adriana Donovan and Patricia Marti and Nicolau Beckmann and Michael T. Dill and Walter Carbone and Sebastian Bergling and Andrea Isken and Matthias Otto M{\"u}ller and Bernd Kinzel and Yi Yang and Xiaohong Mao and Thomas B. Nicholson and Raffaella Zamponi and Paola Capodieci and Reginald Valdez and Daniel J. Rivera and Andreas Loew and Chinweike Ukomadu and Luigi Maria Terracciano and Tewis Bouwmeester and F. Z. Cong and Markus H Heim and Stuart J Forbes and Heinz Ruffner and Jan S. Tchorz},
  journal={Nature Cell Biology},
LGR4/5 receptors and their cognate RSPO ligands potentiate Wnt/β-catenin signalling and promote proliferation and tissue homeostasis in epithelial stem cell compartments. In the liver, metabolic zonation requires a Wnt/β-catenin signalling gradient, but the instructive mechanism controlling its spatiotemporal regulation is not known. We have now identified the RSPO–LGR4/5–ZNRF3/RNF43 module as a master regulator of Wnt/β-catenin-mediated metabolic liver zonation. Liver-specific LGR4/5 loss of… CONTINUE READING
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