The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

@article{PlanasPaz2016TheRM,
  title={The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size},
  author={Lara Planas-Paz and Vanessa Orsini and Luke Boulter and Diego Calabrese and Monika Pikiolek and Florian Nigsch and Yang Xie and Guglielmo Roma and Adriana Donovan and Patricia Marti and Nicolau Beckmann and Michael T. Dill and Walter Carbone and Sebastian Bergling and Andrea Isken and Matthias Otto M{\"u}ller and Bernd Kinzel and Yi Yang and Xiaohong Mao and Thomas B. Nicholson and Raffaella Zamponi and Paola Capodieci and Reginald Valdez and Daniel J. Rivera and Andreas Loew and Chinweike Ukomadu and Luigi Maria Terracciano and Tewis Bouwmeester and F. Z. Cong and Markus H Heim and Stuart J Forbes and Heinz Ruffner and Jan S. Tchorz},
  journal={Nature Cell Biology},
  year={2016},
  volume={18},
  pages={467-479}
}
LGR4/5 receptors and their cognate RSPO ligands potentiate Wnt/β-catenin signalling and promote proliferation and tissue homeostasis in epithelial stem cell compartments. In the liver, metabolic zonation requires a Wnt/β-catenin signalling gradient, but the instructive mechanism controlling its spatiotemporal regulation is not known. We have now identified the RSPO–LGR4/5–ZNRF3/RNF43 module as a master regulator of Wnt/β-catenin-mediated metabolic liver zonation. Liver-specific LGR4/5 loss of… CONTINUE READING
Highly Cited
This paper has 28 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Comparative regenerative mechanisms across different mammalian tissues

npj Regenerative Medicine • 2018
View 5 Excerpts
Highly Influenced

Chemical Modulation of WNT Signaling in Cancer.

Progress in molecular biology and translational science • 2018
View 1 Excerpt

Glucagon contributes to liver zonation

Proceedings of the National Academy of Sciences of the United States of America • 2018
View 1 Excerpt

LGR4 modulates breast cancer initiation, metastasis, and cancer stem cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2018

References

Publications referenced by this paper.
Showing 1-10 of 56 references