The RR1 gene of herpes simplex virus type 1 is uniquely trans activated by ICP0 during infection.

@article{Desai1993TheRG,
  title={The RR1 gene of herpes simplex virus type 1 is uniquely trans activated by ICP0 during infection.},
  author={Prashant G. Desai and Ramesh Ramakrishnan and Z W Lin and B Osak and Joseph Charles Glorioso and Michael Levine},
  journal={Journal of virology},
  year={1993},
  volume={67 10},
  pages={6125-35}
}
As has been demonstrated for herpes simplex virus type 2, we show in this report that the herpes simplex virus type 1 ribonucleotide reductase large subunit (RR1) gene is trans activated in transient transfection assays by VP16 and ICP0 but not by ICP4. Deletion analysis demonstrated that responsiveness to induction to VP16 resides in an octamer/TAATGARAT sequence of the RR1 promoter and that the TATA box alone is sufficient to provide induction by ICP0. The induction of the RR1 gene by ICP0… CONTINUE READING

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