The RPA32 subunit of human replication protein A contains a single-stranded DNA-binding domain.

@article{Bochkareva1998TheRS,
  title={The RPA32 subunit of human replication protein A contains a single-stranded DNA-binding domain.},
  author={Elena Bochkareva and Lori Frappier and Aled M. Edwards and Alexey Bochkarev},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 7},
  pages={3932-6}
}
Replication protein A (RPA) is a conserved nuclear single-stranded DNA (ssDNA)-binding protein. Human RPA (hRPA) comprises three subunits of approximately 70, 32, and 14 kDa (hRPA70, hRPA32 and hRPA14). RPA is known to bind ssDNA through two ssDNA-binding domains in the RPA70 subunit. Here, we demonstrate that the complex of hRPA32 and hRPA14 has an ssDNA-binding domain. Limited proteolysis of the hRPA14.32 complex defined a core dimer composed of the central region of hRPA32 (amino acids 43… CONTINUE READING
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