The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease

@article{Chong2008TheRE,
  title={The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease},
  author={Mark M. W. Chong and Jeffrey P. Rasmussen and Alexander Y Rudensky and Dan R. Littman},
  journal={The Journal of Experimental Medicine},
  year={2008},
  volume={205},
  pages={2005 - 2017}
}
MicroRNAs (miRNAs) are implicated in the differentiation and function of many cell types. We provide genetic and in vivo evidence that the two RNaseIII enzymes, Drosha and Dicer, do indeed function in the same pathway. These have previously been shown to mediate the stepwise maturation of miRNAs (Lee, Y., C. Ahn, J. Han, H. Choi, J. Kim, J. Yim, J. Lee, P. Provost, O. Radmark, S. Kim, and V.N. Kim. 2003. Nature. 425:415-419), and genetic ablation of either within the T cell compartment, or… CONTINUE READING

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