The RNA structurome: transcriptome-wide structure probing with next-generation sequencing.

@article{Kwok2015TheRS,
  title={The RNA structurome: transcriptome-wide structure probing with next-generation sequencing.},
  author={Chun Kit Kwok and Yin Tang and Sarah M. Assmann and Philip C. Bevilacqua},
  journal={Trends in biochemical sciences},
  year={2015},
  volume={40 4},
  pages={221-32}
}
RNA folds into intricate structures that enable its pivotal roles in biology, ranging from regulation of gene expression to ligand sensing and enzymatic functions. Therefore, elucidating RNA structure can provide profound insights into living systems. A recent marriage between in vivo RNA structure probing and next-generation sequencing (NGS) has revolutionized the RNA field by enabling transcriptome-wide structure determination in vivo, which has been applied to date to human cells, yeast… CONTINUE READING