The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin.


Structural, biochemical, and genetic studies have led to proposals that a mobile element of multisubunit RNA polymerases, the Trigger Loop (TL), plays a critical role in catalysis and can be targeted by antibiotic inhibitors. Here we present evidence that the Saccharomyces cerevisiae RNA Polymerase II (Pol II) TL participates in substrate selection. Amino… (More)
DOI: 10.1016/j.molcel.2008.04.023

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