The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer.

@article{Drygin2010TheRP,
  title={The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer.},
  author={Denis Drygin and William G. Rice and Ingrid Grummt},
  journal={Annual review of pharmacology and toxicology},
  year={2010},
  volume={50},
  pages={131-56}
}
The RNA polymerase I (Pol I) transcription machinery in the nucleolus is the key convergence point that collects and integrates a vast array of information from cellular signaling cascades to regulate ribosome production that in turn guides cell growth and proliferation. Cancer cells commonly harbor mutations that inactivate tumor suppressors, hyperactivate oncogenes, and upregulate protein kinases, all of which promote Pol I transcription and drive cell proliferation. The intimate balance… CONTINUE READING
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