The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

@article{Yoneyama2004TheRH,
  title={The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses},
  author={Mitsutoshi Yoneyama and Mika Kikuchi and Takashi Natsukawa and Noriaki Shinobu and Tadaatsu Imaizumi and Makoto Miyagishi and Kazunari Taira and Shizuo Akira and Takashi Fujita},
  journal={Nature Immunology},
  year={2004},
  volume={5},
  pages={730-737}
}
Intracellular double-stranded RNA (dsRNA) is a chief sign of replication for many viruses. Host mechanisms detect the dsRNA and initiate antiviral responses. In this report, we identify retinoic acid inducible gene I (RIG-I), which encodes a DExD/H box RNA helicase that contains a caspase recruitment domain, as an essential regulator for dsRNA-induced signaling, as assessed by functional screening and assays. A helicase domain with intact ATPase activity was responsible for the dsRNA-mediated… 

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