The RNA exosome promotes transcription termination of backtracked RNA polymerase II

@article{Lemay2014TheRE,
  title={The RNA exosome promotes transcription termination of backtracked RNA polymerase II},
  author={Jean-François Lemay and M elissa Larochelle and Samuel Marguerat and Sophie R. Atkinson and J{\"u}rg B{\"a}hler and François Bachand},
  journal={Nature Structural &Molecular Biology},
  year={2014},
  volume={21},
  pages={919-926}
}
The exosome is an RNA-decay complex that constantly monitors transcription and contributes to post-transcriptional turnover of faulty mRNAs. Yet how nuclear RNA surveillance by the exosome is coordinated with transcription is still unknown. Here we show that the RNA exosome of Schizosaccharomyces pombe can target the transcription machinery by terminating transcription events associated with paused and backtracked RNA polymerase II (RNAPII); this is contrary to the notion that the exosome acts… CONTINUE READING
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