The RNA component of human telomerase

@article{Feng1995TheRC,
  title={The RNA component of human telomerase},
  author={J. Feng and W. Funk and S.-S. Wang and SL Weinrich and AA Avilion and C. Chiu and R. Adams and E. Chang and RC Allsopp and J. Yu and et al.},
  journal={Science},
  year={1995},
  volume={269},
  pages={1236 - 1241}
}
Eukaryotic chromosomes are capped with repetitive telomere sequences that protect the ends from damage and rearrangements. Telomere repeats are synthesized by telomerase, a ribonucleic acid (RNA)-protein complex. Here, the cloning of the RNA component of human telomerase, termed hTR, is described. The template region of hTR encompasses 11 nucleotides (5'-CUAACCCUAAC) complementary to the human telomere sequence (TTAGGG)n. Germline tissues and tumor cell lines expressed more hTR than normal… Expand
2,214 Citations
Expression and suppression of human telomerase RNA.
  • S. Li, E. Blackburn
  • Biology, Medicine
  • Cold Spring Harbor symposia on quantitative biology
  • 2006
Forms and Functions of Telomerase RNA
Integrator is a key component of human telomerase RNA biogenesis
Telomerase in Breast Cancer: A Critical Evaluation
Human Telomerase and Its Regulation
Telomerase RNA is more than a DNA template
Inhibition of human telomerase by a retrovirus expressing telomeric antisense RNA.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 45 REFERENCES
Telomerase activity in human ovarian carcinoma.
...
1
2
3
4
5
...