The RNA cleavage activity of RNA polymerase III is mediated by an essential TFIIS-like subunit and is important for transcription termination.

@article{Chdin1998TheRC,
  title={The RNA cleavage activity of RNA polymerase III is mediated by an essential TFIIS-like subunit and is important for transcription termination.},
  author={St{\'e}phane Ch{\'e}din and Michel Riva and Patrick Schultz and A. Sentenac and Christophe Carles},
  journal={Genes & development},
  year={1998},
  volume={12 24},
  pages={3857-71}
}
Budding yeast RNA polymerase III (Pol III) contains a small, essential subunit, named C11, that is conserved in humans and shows a strong homology to TFIIS. A mutant Pol III, heterocomplemented with Schizosaccharomyces pombe C11, was affected in transcription termination in vivo. A purified form of the enzyme (Pol III Delta), deprived of C11 subunit, initiated properly but ignored pause sites and was defective in termination. Remarkably, Pol III Delta lacked the intrinsic RNA cleavage activity… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 57 extracted citations

Functional Architecture of RNA Polymerase I

View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…