The RNA binding site of bacteriophage MS2 coat protein.

  title={The RNA binding site of bacteriophage MS2 coat protein.},
  author={David S. Peabody},
  journal={The EMBO journal},
  volume={12 2},
The coat protein of the RNA bacteriophage MS2 binds a specific stem-loop structure in viral RNA to accomplish encapsidation of the genome and translational repression of replicase synthesis. In order to identify the structural components of coat protein required for its RNA binding function, a series of repressor-defective mutants has been isolated. To ensure that the repressor defects were due to substitution of binding site residues, the mutant coat proteins were screened for retention of the… CONTINUE READING
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