The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity.

@article{Tran2010TheRP,
  title={The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity.},
  author={Uyen Tran and Lise D.J Zakin and Axel Schweickert and Raman Agrawal and Remziye D{\"o}ger and Martin Blum and Edward M De Robertis and Oliver Wessely},
  journal={Development},
  year={2010},
  volume={137 7},
  pages={1107-16}
}
The RNA-binding protein Bicaudal C is an important regulator of embryonic development in C. elegans, Drosophila and Xenopus. In mouse, bicaudal C (Bicc1) mutants are characterized by the formation of fluid-filled cysts in the kidney and by expansion of epithelial ducts in liver and pancreas. This phenotype is reminiscent of human forms of polycystic kidney disease (PKD). Here, we now provide data that Bicc1 functions by modulating the expression of polycystin 2 (Pkd2), a member of the transient… CONTINUE READING
57 Citations
54 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 57 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 54 references

and targets the transcription factor Xlim 1 / Lhx 1

  • P. Anderson, N. Kedersha
  • 2008
Highly Influential
7 Excerpts

Similar Papers

Loading similar papers…