The RNA-binding protein Y14 inhibits mRNA decapping and modulates processing body formation

@inproceedings{Chuang2013TheRP,
  title={The RNA-binding protein Y14 inhibits mRNA decapping and modulates processing body formation},
  author={T Chuang and W. -C. Chang and K. Lee and Woan-Yuh Tarn},
  booktitle={Molecular biology of the cell},
  year={2013}
}
The exon-junction complex (EJC) deposited on a newly spliced mRNA plays an important role in subsequent mRNA metabolic events. Here we show that an EJC core heterodimer, Y14/Magoh, specifically associates with mRNA-degradation factors, including the mRNA-decapping complex and exoribonucleases, whereas another core factor, eIF4AIII/MLN51, does not. We also demonstrate that Y14 interacts directly with the decapping factor Dcp2 and the 5' cap structure of mRNAs via different but overlapping… CONTINUE READING

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