The RNA-binding protein Unr prevents mouse embryonic stem cells differentiation toward the primitive endoderm lineage.

@article{Elatmani2011TheRP,
  title={The RNA-binding protein Unr prevents mouse embryonic stem cells differentiation toward the primitive endoderm lineage.},
  author={Habiba Elatmani and Virginie Dormoy-Raclet and Pierre Dubus and F. Dautry and Claire Chazaud and H{\'e}l{\`e}ne Jacquemin-Sablon},
  journal={Stem cells},
  year={2011},
  volume={29 10},
  pages={1504-16}
}
The maintenance of embryonic stem cells (ESCs) pluripotency depends on key transcription factors, chromatin remodeling proteins, and microRNAs. The roles of RNA-binding proteins are however poorly understood. We report that the cytoplasmic RNA-binding protein Unr prevents the differentiation of ESCs into primitive endoderm (PrE). We show that unr knockout (unr(-/-) ) ESCs spontaneously differentiate into PrE, and that Unr re-expression in unr(-/-) ESCs reverses this phenotype. Nevertheless, unr… CONTINUE READING
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