The RNA-binding protein Sam68 is a multifunctional player in human cancer.

@article{Bielli2011TheRP,
  title={The RNA-binding protein Sam68 is a multifunctional player in human cancer.},
  author={Pamela Bielli and Roberta Bus{\`a} and Maria Paola Paronetto and Claudio Sette},
  journal={Endocrine-related cancer},
  year={2011},
  volume={18 4},
  pages={R91-R102}
}
Src associated in mitosis, of 68 kDa (Sam68) is a KH domain RNA-binding protein that belongs to the signal transduction and activation of RNA family. Although ubiquitously expressed, Sam68 plays very specialized roles in different cellular environments. In most cells, Sam68 resides in the nucleus and is involved in several steps of mRNA processing, from transcription, to alternative splicing, to nuclear export. In addition, Sam68 translocates to the cytoplasm upon cell stimulation, cell cycle… CONTINUE READING

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