The RNA-binding protein HuR is essential for the B cell antibody response

  title={The RNA-binding protein HuR is essential for the B cell antibody response},
  author={Manuel D D{\'i}az-Mu{\~n}oz and Sarah E Bell and Kirsten A. Fairfax and Elisa Monz{\'o}n-Casanova and Adam F Cunningham and Mar Gonzalez-Porta and Simon R. Andrews and Victoria I. Bunik and Kathi Zarnack and Toma{\vz} Curk and Ward A Heggermont and Stephane R B Heymans and Gary E Gibson and D. L. Kontoyiannis and Ule Jernej and Martin Turner},
  journal={Nature Immunology},
Post-transcriptional regulation of mRNA by the RNA-binding protein HuR (encoded by Elavl1) is required in B cells for the germinal center reaction and for the production of class-switched antibodies in response to thymus-independent antigens. Transcriptome-wide examination of RNA isoforms and their abundance and translation in HuR-deficient B cells, together with direct measurements of HuR-RNA interactions, revealed that HuR-dependent splicing of mRNA affected hundreds of transcripts, including… CONTINUE READING
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