The RNA binding protein CsrA controls cyclic di-GMP metabolism by directly regulating the expression of GGDEF proteins.

@article{Jonas2008TheRB,
  title={The RNA binding protein CsrA controls cyclic di-GMP metabolism by directly regulating the expression of GGDEF proteins.},
  author={Kristina Jonas and Adrianne Nehrling Edwards and Roger Simm and Tony Romeo and Ute R{\"o}mling and Ojar Melefors},
  journal={Molecular microbiology},
  year={2008},
  volume={70 1},
  pages={236-57}
}
The carbon storage regulator CsrA is an RNA binding protein that controls carbon metabolism, biofilm formation and motility in various eubacteria. Nevertheless, in Escherichia coli only five target mRNAs have been shown to be directly regulated by CsrA at the post-transcriptional level. Here we identified two new direct targets for CsrA, ycdT and ydeH, both of which encode proteins with GGDEF domains. A csrA mutation caused mRNA levels of ycdT and ydeH to increase more than 10-fold. RNA… CONTINUE READING

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