The RNA annealing mechanism of the HIV-1 Tat peptide: conversion of the RNA into an annealing-competent conformation

@inproceedings{Doetsch2011TheRA,
  title={The RNA annealing mechanism of the HIV-1 Tat peptide: conversion of the RNA into an annealing-competent conformation},
  author={Martina Doetsch and Boris F{\"u}rtig and Thomas Gstrein and Sabine Stampfl and Ren{\'e}e Schroeder},
  booktitle={Nucleic acids research},
  year={2011}
}
The annealing of nucleic acids to (partly) complementary RNA or DNA strands is involved in important cellular processes. A variety of proteins have been shown to accelerate RNA/RNA annealing but their mode of action is still mainly uncertain. In order to study the mechanism of protein-facilitated acceleration of annealing we selected a short peptide, HIV-1 Tat(44-61), which accelerates the reaction efficiently. The activity of the peptide is strongly regulated by mono- and divalent cations… CONTINUE READING
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