The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis

Abstract

Telomerase is a ribonucleoprotein (RNP) enzyme that maintains the ends of linear eukaryotic chromosomes and whose activation is a hallmark of 90% of all cancers. This RNP minimally contains a reverse transcriptase protein subunit (TERT) that catalyzes telomeric DNA synthesis and an RNA subunit (TER) that has templating, architectural and protein-scaffolding… (More)
DOI: 10.1038/nsmb.2174

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