The RNA Splicing Response to DNA Damage.

@article{Shkreta2015TheRS,
  title={The RNA Splicing Response to DNA Damage.},
  author={Lulzim Shkreta and Benoit Chabot},
  journal={Biomolecules},
  year={2015},
  volume={5 4},
  pages={2935-77}
}
The number of factors known to participate in the DNA damage response (DDR) has expanded considerably in recent years to include splicing and alternative splicing factors. While the binding of splicing proteins and ribonucleoprotein complexes to nascent transcripts prevents genomic instability by deterring the formation of RNA/DNA duplexes, splicing factors are also recruited to, or removed from, sites of DNA damage. The first steps of the DDR promote the post-translational modification of… CONTINUE READING
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Mechanisms and Regulation of Alternative Pre-mRNA Splicing.

Annual review of biochemistry • 2015
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