The RNA Replication of Hydroxylamine-inactivated Polioviruses

If cells are exposed to a mixture of hydroxylamine inactivated and infectious viruses the total rate of viral RNA-replication is lower than if the cells are infected with the same number of infectious viruses alone. This inhibitory influence of inactivated viruses depends on the ratio of infectious: inactivated viruses in the inoculum. One lethal hit by… CONTINUE READING